Australia will submit a new-look side for the Champions Trophy with four replacements needed following injuries and retirement.
Josh Hazlewood and Pat Cummins were the two latest players to be ruled out with injuries.
The news came on the same day Marcus Stoinis announced his retirement from ODI cricket.
RECAP: Australia v Sri Lanka second Test, day one
Mitchell Marsh was also ruled out recently with an ongoing back injury.
Mitchell Starc is the last man standing for the Champions Trophy with Pat Cummins, Josh Hazlewood and Mitch Marsh ruled out. Â Getty
"Unfortunately Pat, Josh and Mitch are managing some ongoing injuries and haven't come up in time for the Champions Trophy," Australia's chairman of selectors, George Bailey, said.
"While disappointing, it does present a great opportunity for other players to perform for Australia in a world event."
With Australia set to play two one-day matches against Sri Lanka after the Test series ends, Sean Abbott, Tanveer Sangha, Cooper Connolly, Spencer Johnson, Jake Fraser-McGurk and Ben Dwarshuis have all been added to the squad.
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The Champions Trophy squad will be finalised on February 12.
With Cummins out, Australia will need a new captain with Andrew McDonald recently confirming Steve Smith and Travis Head are the two men in the frame.